Agapurin: instructions for using the medicine, structure, Contraindications

Pentoxifylline reduces blood viscosity, mostly in capillaries. Consequently – improved tissue oxygen supply and blood flow.

Agapurin: indications and dosage

Agapurine is used:

• In chronic peripheral arterial and arteriovenous circulatory disorders, caused by atherosclerosis, for patients with diabetes, inflammation, dystrophic disorders (hip ulcer, post-thrombotic syndrome, gangrene, frostbite) and angioneuropathy (acrocyanosis, paraesthesia, Raynaud's disease)
• For disorders of the cerebrovascular circulation
• In acute and chronic retinal and choroidal vascular insufficiency
• In acute functional disorders of the inner ear

In the first week of treatment, the initial dose for adults is 200 mg pentoxifylline, taking the drug three times a day. Patients with chronic diseases, usually take 100 mg pentoxifylline three times a day. In case of hypotension, negative reactions from the central nervous system or gastrointestinal tract, starting dose may be reduced to 100 mg pentoxifylline three times a day. Patients with renal impairment are advised to reduce the dose by 50 – 70% from normal dose, creatine level> 400 mmol / l.

The maximum daily dose is 1200 mg and should not be exceeded.

Dragee should be taken whole, better at the same time during meals or after. Drink some liquid.

Agapurin: overdose

Nausea may occur in case of drug overdose., dizziness, tachycardia or low blood pressure. Symptoms not excluded, including fever, tides, excitation, loss of consciousness.

In case of overdose, stop taking the drug, wash out the stomach, take activated charcoal. In order to prevent complications in acute overdose, general and specialized medical supervision is required..

Agapurin: side effects

Agapurin is generally well tolerated., but sometimes there may be such side reactions: tachycardia, gipotenziya, symptoms of angina pectoris, arrhythmia, bleeding in various organs, gipoglikemiâ. Possible nausea, vomiting and a feeling of fullness in the stomach. Headache not ruled out, nervousness, excitation, bad dream, high perspiration. Sometimes there is hypersensitivity (hives, rash, itch), but allergic manifestations disappear after the termination or termination of treatment.

Agapurin: Contraindications

Agapurin is contraindicated in:

• Hypersensitivity of the body to the components of the drug
• With bleeding, retinal bleeding
• During pregnancy and lactation
• For the treatment of children and adolescents under the age of 18 years

With caution, the drug should be prescribed to patients with such cardiac arrhythmias., acute myocardial infarction, with severe hepatic dysfunction, patients at risk of overdose and adverse reactions and hypotension. Patients with hemorrhagic diathesis also require caution..

Agapurin: interactions with other drugs and alcohol

Pentoxifylline enhances the effect of antihypertensive and other vasodilators, which can cause severe hypotension. A significant decrease in blood pressure is possible when used simultaneously with adrenergic and ganglionic blockers. Simultaneous use of xanthines or adrenergic substances leads to stimulation of the central nervous system.. Higher doses of pentoxifylline potentiate the effect of oral hypoglycemic agents and insulin. With time, recommended adjustment of antidiabetic therapy due to risk of hypoglycemia. Blood glucose levels are recommended to be measured more frequently. The incidence of complications of hemorrhage is increased in patients, who are being treated concomitantly with anticoagulants, thrombolytic and antiplatelet agents. In these patients, prothrombin time should be measured more frequently..

Agapurin: composition and properties

Structure:

IN 1 dragee contains pentoxifylline 100 mg. Excipients: lactose,corn starch, talc, magnesium stearate, colloidal silicon dioxide, carmellose sodium, mottled sucrose, powdered sucrose, acacia, titanium dioxide.

Agapurin: release form

Drop.

Agapurin: pharmachologic effect

due to inhibition of the phosphodiesterase enzyme, Pentoxifylline relaxes the smooth muscles of the arterioles., followed by accumulation of cyclic AMP. Pentoxifylline reduces blood viscosity, mostly in capillaries. Consequently – improved tissue oxygen supply and blood flow. It inhibits platelet adhesion and aggregation. Pentoxifylline increases the elasticity and flexibility of red blood cells, increases the concentration of ATP in the external environment. Pentoxifylline has cytoprotective and anti-inflammatory effects, based on a decrease in the activation of neutrophils and a decrease in the synthesis of macrophage cytokines. These properties can be used in the treatment of sepsis, bronchial asthma and endotoxic shock.

Agapurin: storage conditions

Keep away from children. The storage temperature should not exceed 25 ° C.

Storage life – 5 years.

Agapurin: general information

• Sales form: on prescription
• Current in-about: Pentoxifylline
• Manufacturer: Zentiva S.A., S.S., Romania
• Farm. Group: Angioprotective drugs