AFOBAZOL

Active material: morfolinoetiltioetoksiʙenzimidazola digidroxlorid
When ATH: N05BX
CCF: Tranquillizer (anxiolytic)
ICD-10 codes (testimony): F10.3, F17, F40, F41.1, F43, F45.3, F48.0, F51.2, I10, i20, J45, K58, M32, N94.3
When CSF: 02.04.05
Manufacturer: OAO Pharmstandard-Leksredstva (Russia)

Pharmaceutical form, composition and packaging

◊ Pills white or white with Valium a color shade, Valium, chamfered.

Excipients: potato starch, microcrystalline cellulose, lactose, povidone, magnesium stearate.

20 PC. – packings Valium planimetric (3) – packs cardboard.

Pharmacological action

Afoʙazol^® – derivative of 2-mercaptobenzimidazole, selective anxiolytic, not belonging to the class of benzodiazepine receptor agonists. It prevents the development of membranozavisimyh changes in GABA-receptor.

The drug has anxiolytic effects with an activating component, not accompanied effect gipnosedativny (sedative effects at the doses detected, in 40-50 times the ED₅₀ for anxiolytic action). There are no muscle relaxant properties of the drug, a negative impact on memory and attention. In applying the drug is not formed drug dependence and withdrawal symptoms do not develop.

Effect of the drug is realized mainly in the form of a combination of anxiolytic (protivotrevozhnogo) stimulating and easy (activating) Effects. Reducing or eliminating anxiety (preoccupation, bad feeling, concerns, irritability), tension (puhlyvost, tearfulness, anxiety, inability to relax, insomnia, fear), and, Consequently, somatic (muscle, touch, Cardiovascular, Breathing, gastrointestinal symptoms), vegetative (dry mouth, Sweating, dizziness), Cognitive (difficulty concentrating, hypomnesia) violations observed on 5-7 days of treatment afobazole^®. The maximum effect is reached at the end 4 week of treatment and lasts an average period posleterapevticheskom 1-2 of the week.

Especially shows the use of the drug in patients with predominantly asthenic personality traits as alarming suspiciousness, uncertainty, increased vulnerability and emotional lability, propensity to emotional stress reactions. Afoʙazol^® non-toxic (LD₅₀ in rats is 1.1 d at ED₅₀ 1 mg).

Pharmacokinetics

Absorption

C_max is 0.13 ± 0.073 g / ml.

Distribution

The average retention time of the drug in the body – 1.6± 0.86. Intensively distributed to well-vascularized organs.

Deduction

T_1/2 is 0.82 no.

Testimony

Anxiety in Adults:

- Generalized anxiety disorder, neurasthenia, adjustment disorder;

- In patients with various somatic (bronchial asthma, Irritable Bowel Syndrome, SLE, CHD, arterial hypertension, Arrhythmia), dermatological and oncological diseases;

- Sleep disorders, associated with anxiety;

- Cardiopsychoneurosis;

- Premenstrual tension;

- Alcohol withdrawal syndrome;

- To facilitate the withdrawal syndrome smoking cessation.

Dosage regimen

The drug is prescribed inside, postprandial. A single dose of 10 mg; daily dose – 30 mg, razdelennaya of 3 receiving during the day. The duration of a course of the drug is 2-4 of the week. If necessary, the daily dose can be increased to 60 mg, and the duration of treatment to 3 months.

Side effect

Maybe: allergic reactions, Individual hypersensitivity.

Contraindications

- Pregnancy;

- Lactation (breast-feeding);

- Up to 18 years;

- Hypersensitivity to the drug.

Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation (breast-feeding).

Cautions

–

Overdose

Symptoms: if a large overdose and intoxication may develop sedation and increased sleepiness without manifestations miorelaxation.

Treatment: as prescribed emergency n / a caffeine-sodium benzoate 20% solution for 1 ml 2-3 times / day.

Drug Interactions

In an application Afobazol^® It has no influence on the effects of ethanol and thiopental.

In an application Afobazol^® potentiates the anticonvulsant effect of carbamazepine.

In an application Afobazol^® causes increased anxiolytic action of diazepam.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children, dry, dark place at a temperature no higher than 25 ° C. Shelf life – 2 year.