Advocate: instructions for using the medicine, structure, Contraindications

Advokard - combination drug, having anti-ischemic, membrane stabilizing, antioxidant, antihypoxic and antisclerotic action.

Advocate: indications and dosage

The drug is used to treat patients, suffering from diseases of the cardiovascular system, including coronary heart disease and various forms of angina pectoris, especially angina pectoris, rest angina and unstable angina.

The drug is used to treat patients with postinfarction and myocardial cardiosclerosis., including diffuse and focal cardiosclerosis.

The drug is prescribed to patients with metabolic myocardiopathy and myocarditis, as well as in the complex therapy of arrhythmias.

The drug is intended for sublingual use. The tablet should be held under the tongue until completely dissolved.. The drug is taken regardless of meals. If it is necessary to achieve a quick effect, the tablet should be sucked., in this case, the therapeutic effect of the drug is achieved within 3-5 minutes. The duration of the course of treatment and the dose of the drug is determined by the attending physician individually for each patient..

The recommended doses of the drug are given in terms of adenosine-5-triphosphate-gluconate-magnesium trisodium salt.

Adults are usually prescribed 10-90 mg of the drug 3-4 once a day.

The duration of treatment usually ranges from 20 to 30 days. If necessary, the course of treatment is repeated later 10-15 days.

Adults with acute attacks of angina or arrhythmias are usually prescribed a single dose of 10-90 mg of the drug until the condition improves..

The maximum daily dose of the drug is 400-600 mg.

Advocate: overdose

When using excessive doses of the drug in patients, the development of headache and dizziness is noted..

No specific antidote. In case of overdose, symptomatic treatment is indicated..

Advocate: side effects

The drug is usually well tolerated by patients, in isolated cases, the development of headache was noted, reducing blood pressure and nausea in patients, who received therapy with Advocard.

Advocate: Contraindications

• Individual hypersensitivity to the components of the drug.
• The drug is not prescribed to patients, suffering from severe bronchial asthma, severe arterial hypotension.
• The drug is not prescribed to patients with collapse, shock and shock states.
• The drug is not used for the treatment of women during pregnancy and lactation., as well as for the treatment of children under the age of 14 years, due to the lack of reliable data on the safety and efficacy of the drug in these categories of patients.
• The drug should be used with caution in elderly patients, the use of the drug in this age group should begin with minimal doses.

The drug can be prescribed during pregnancy by the attending physician in case of, if the expected benefit to the mother is higher, than the potential risks to the fetus.

If it is necessary to use the drug during lactation, you should consult with your doctor and decide on the possible interruption of breastfeeding..

Advocate: interactions with other drugs and alcohol

With the combined use of the drug with drugs, lowering blood pressure, there is an increase in the therapeutic effect of the latter. This effect is most pronounced with the combined use of the drug with nitrates..

The drug should not be used in combination with sildenafil citrate., concomitant use of these drugs can lead to the development of severe hypotension.

Advocate: composition and properties

1 Advokard sublingual tablet contains:

Adenosine-5-triphosphate-gluconate-magnesium trisodium salt - 29.25 mg;

Molsidomine - 0.3 mg;

Folic acid - 0.45 mg;

Excipients, including powdered sugar.

Advocate: release form

Sublingual tablets Advokard by 10 pieces in blisters, by 1 or 2 blisters in a cardboard box.

Advocate: pharmachologic effect

The composition of the drug includes three active components - adenosine-5-triphosphate-gluconate-magnesium (II) trisodium salt, molsidomine and folic acid. The active components of the drug complement and enhance the therapeutic effects of each other.. Mechanism of action and therapeutic effects of the drug based on the pharmacological properties of the active ingredients.

Adenosine-5-triphosphate gluconate-magnesium (II) trisodium salt compound, having pharmacological properties similar to ATP, but more resistant to enzymes. The mechanism of action of the drug is based on its ability to stimulate purinergic receptors., as a result, the penetration of calcium ions through cell membranes is reduced. The drug has an anti-ischemic effect, stabilizes the membranes of myocardial and vascular cells, reduces the severity of arrhythmias. Besides, adenosine-5-triphosphate gluconate-magnesium (II) trisodium salt contributes to the normalization of energy metabolism, restores the structure of the lipid layer of cell membranes, regulates the activity of membrane-bound enzymes and improves antioxidant protection of the myocardium. The drug regulates the penetration of ions through the cell membrane, reduces oxygen consumption by the heart muscle and improves myocardial function in conditions of hypoxia.

Molsidomin is a medicinal substance, with a pronounced vasodilating effect. In the body, molsidomine is metabolized to form two active metabolites.. The mechanism of action of the drug is associated with the release of nitric oxide, which reduces the tone of the smooth muscle wall of blood vessels and causes dilatation of the coronary vessels. Besides, molsidomine reduces the load on the heart muscle, has an antiplatelet effect and improves hemodynamics. The drug is not addictive.

Folic acid - has a pronounced anti-sclerotic effect, and also takes part in various metabolic processes. The mechanism of the anti-sclerotic action of folic acid is based on its ability to reduce the level of homocysteine.. Besides, folic acid, regulating the course of metabolic processes in myocardial tissues, increases the functional activity of the heart muscle.

The active components of the drug normalize the level of potassium and magnesium in the tissues, contribute to the improvement of hemodynamics, improve the functional state of the left ventricle and blood circulation in the coronary vessels, increase cardiac contractility and cardiac output.

In patients with angina pectoris, the drug reduces the frequency and severity of attacks, increases exercise tolerance.

In patients with supraventricular tachycardia, parasystole and extrasystolic arrhythmia, the drug has a pronounced antiarrhythmic effect.

Advocate: storage conditions

The drug is recommended to be stored in a dry place away from direct sunlight at a temperature of 3 to 5 degrees Celsius.

The shelf life of the drug, regardless of the form of release - 3 year.

Advocate: general information

Sales form: over-the-counter

Farm. Group: Antianginal agents of other groups