Adenosine Phosphate
When ATH:
C01EB10
Characteristic.
Metabolic means. The white crystalline powder;. It is soluble in water (easily soluble in boiling water), insoluble in 1% solution of sodium bicarbonate. Molecular weight 347,22.
Pharmacological action.
Regulatory redox processes, metabolic, vasodilator, antiagregatine.
Application.
Acute "intermittent" porphyria, saturnism (polinevritichesky syndrome), acute thrombosis of the superficial and deep veins of the extremities, Acute occlusion of the arteries (in step conservative treatment and postoperatively), occlusive disease, venectomy (before- and postoperative period), chronic venous insufficiency, tromboflebit, secondary vascular syndromes, caused by lesions of the spine. Post-burn complications: nonhealing ulcers, trophic ulcers, post-burn. Gepatotserebralynaya dystrophy (Wilson's disease Konovalova-Westphalia) and other inherited diseases of the CNS, chronic hepatitis, cirrhosis of the liver, duodenal ulcer, multiple sclerosis, CHD, congestive heart failure, asthenia, psoriasis, diabetic retinopathy - as part of combination therapy; to speed up the recovery of sportsmen.
Contraindications.
Hypersensitivity, myocardial infarction, hemorrhagic stroke.
Side effects.
Dizziness, noise in my head, flushing, tachycardia, low blood pressure, dyspnoea, nausea, allergic reactions (These phenomena are at lower doses or after discontinuation of the drug), anaphylactoid reactions after injection.
Cooperation.
Dipyridamole enhances the effect of, theophylline, caffeine and other xanthines - weaken.
Dosing and Administration.
Inside, / m. In acute "intermittent" porphyria and vascular diseases of extremities: IM - 0.04–0.06 g 2–5 times a day, in the future, the course of injections is reduced and switched to oral administration - according to 0,05 g 2-3 times per day. For other diseases - inside, 0.025–0.05 yr each (to 0,15 g) 2 once a day.
Precautions.
Do not use in children, tk. efficacy and safety have not been established. If patients after injection was noted dyspnea or heat in the breast, The following injection should not be pursued.
