Adaptol: instructions for using the medicine, structure, Contraindications
Active material: 2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo-(3,3,0)-oktandïon
When ATH: N05BX
CCF: Tranquillizer (anxiolytic)
ICD-10 codes (testimony): F17, F40, F45.3, F48.0
Manufacturer: OLINEFARM AS (Latvia)
Pharmaceutical form, composition and packaging
Pills white or nearly white, round, Valium, a facet and Valium.
| 1 tab. | |
| 2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo-(3,3,0)-oktandïon | 500 mg |
Excipients: methyl cellulose, calcium stearate.
10 PC. – packings Valium planimetric (1) – packs cardboard.
10 PC. – packings Valium planimetric (2) – packs cardboard.
Adaptol: pharmachologic effect
Anxiolytic (tranquillizer).
Adaptol is similar in chemical structure to the body's natural metabolites – its molecule consists of two fragments of methylated urea, included in the bicyclic structure.
Adaptol acts on structures Activity, within the limbic-reticular complex, in particular, in the area of the hypothalamus emotiogenic, and also has an effect on all 4 the main neurotransmitter systems: GABA-, kholin-, Serotonin- and adrenergicheskuyu, helping them balance and integration, but has no peripheral actions adrenonegativnogo.
It eliminates or reduces anxiety, alarm, fear, inner emotional tension and irritability. The calming effect is not accompanied by muscle relaxation and impaired motor coordination.
It does not reduce the mental and motor activity, Adaptol so can be used during the work day or school. It does not create high spirits, feelings of euphoria.
Hypnotic action has not, but enhances the effect of hypnotics and improves during sleep when violations.
Adaptol easier or relieves nicotine withdrawal.
Also it has a calming effect nootropic. In clinical studies found, Adaptol that improves consistency, connectivity and speed of thinking, improves focus and mental performance, not encouraging signs of productive psychopathological disorders: delirium, pathological emotional activity.
Adaptol: pharmacokinetics
Absorption
Once inside Adaptol well absorbed from the gastrointestinal tract (77-80%). Cmax the active substance in plasma is achieved by 0.5 h after dosing. High concentration of active substance is retained within 3-4 no, then gradually decreases.
Distribution
To 40% the dose associated with erythrocytes. The remainder of the blood plasma is in a free form, therefore, the active substance is distributed freely throughout the body and readily passes cell membranes.
Metabolism
Active ingredient is not metabolized and is not accumulated in the body.
Deduction
About 55-70% of the dose excreted in urine, the rest - in the feces as unchanged during the day.
Adaptol: testimony
- Neuroses and neurosis-like states, occurring with symptoms of irritability, emotional instability, anxiety and fear;
- to improve the tolerance of antipsychotics and tranquilizers in order to eliminate the somatovegetative and neurological side effects caused by them;
- Cardialgia different genesis, not related to coronary artery disease;
- In the complex therapy as a means of, reducing the craving to smoke tobacco.
Adaptol: dosing regimen
The drug is taken orally with or without food for 500 mg 2-3 times / day. The maximum single dose is 3 g, daily – 10 g. The duration of treatment a few days before 2-3 Months.
In the treatment as funds, reducing the craving to smoke tobacco, appoint 600-900 mg 3 times / day for 5-6 weeks.
If time has not been accepted yet another dose, The course of treatment in the previously assigned doses.
Adaptol: side effects
When used in high doses: possible – allergic reaction and dyspepsia (should stop taking the drug), lowering of blood pressure and body temperature (normalize yourself).
Generally well tolerated Adaptol.
Adaptol: Contraindications
- Hypersensitivity to the drug.
Adaptol: Pregnancy and lactation
Adaptol penetrates well into all tissues and body fluids. There is a sufficient number of clinical observations on the use of the drug during pregnancy and lactation (breast-feeding), therefore prescribe a drug of this category of patients is not recommended.
Adaptol: Special instructions
Addictive, addiction and withdrawal syndrome to Adaptol have not been established.
The patient must inform the doctor about any side effects, occur during treatment with.
Effects on ability to drive vehicles and management mechanisms
There was no impact Adaptol the ability to perform work, require high concentration and speed of psychomotor reactions.
Adaptol: overdose
The drug has low toxicity. If you suspect an overdose should be carried out conventional methods of detoxification, incl. gastric lavage.
Adaptol: drug interaction
The simultaneous use of Adaptol with neuroleptics, trankvilizatorami (incl. ʙenzodiazepinami), hypnotics, antidepressants and psychostimulants.
Adaptol: terms of dispensing from pharmacies
The drug is released under the prescription.
Adaptol: terms and conditions of storage
The drug should be stored out of reach of children, dry place. Shelf life – 4 year.
