Adant – it is a pain reliever, associated with traumatic changes in cartilage and other joints. The instruction says, that the drug is essentially a synovial fluid prosthesis. The drug restores its properties and functions. This allows you to turn the natural process of synthesis in the right direction.. The drug can improve joint mobility, relieve pain and reduce inflammation. This process happens quite quickly..

Adant: indications and dosage

• Osteoarthritis of the knee and shoulder joints
• Osteoarthritis of the carpometacarpal joint I, II and III degrees
• Pain and limitation of movement of other synovial joints, as a consequence of degenerative and post-traumatic changes

In general, intra-articular administration of the drug is recommended once a week for 5 weeks in a row.

The drug should be injected directly into the cavity of the knee joint, into the shoulder joint (articular cavity, subacromial bursa or tendon sheath of the long head of the biceps), carpometacarpal joint or other affected synovial joints.

In the case of the carpometacarpal joint, two routes of administration are recommended depending on the severity of osteoarthritis: lateral external method (I degree of rhizarthrosis) and interdigital / in the commissure of the first finger (II and III degrees of rhizarthrosis).

Nonetheless, the choice of one or another method of drug administration depends on the individual characteristics of each patient; drug administration is best performed under endoscopic control.

Anyway, dose selection depends on the severity of symptoms.

Unnecessarily. Adant is injected into the joint cavity, the process of drug administration should be carried out in compliance with all asepsis rules.

If during the 5 weeks of treatment, there is no relief of symptoms, treatment should be discontinued.

If there are signs of synovial fluid retention, arthrocentesis is recommended.

The introduction of the drug Adant into the bloodstream is not allowed..

Do not inject the drug into the tissues of the eye.

Given the high viscosity of the drug, use of needles No. 21-23G is recommended

Before use, warm the drug to room temperature.

The drug should be used once immediately after opening the package.. Unused drug should be disposed of in compliance with the necessary regulatory requirements..

Adant: overdose

Cases of drug overdose are unknown.

Adant: side effects

In some cases, a local allergic reaction may develop., such as hives and itching.

In this case, the administration of the drug should be stopped and appropriate therapy prescribed..

There are isolated reports of the development of pain (mainly, transient pain after injection) and swelling.

Patients may complain of swelling, redness, burning sensation and heaviness at the injection site.

Shock reactions are extremely rare..

In this case, further administration of the drug should be stopped., monitor the patient and prescribe appropriate therapy.

Adant: Contraindications

Hypersensitivity to the active substance.

The drug can cause an exacerbation of the inflammatory process in patients with osteoarthritis.

In this case, the introduction of the drug is recommended after the relief of inflammatory symptoms..

In rare cases, pain is noted after the administration of the drug..

To prevent the development of pain after the injection of the drug, it is recommended to remain calm in the affected joint..

The introduction of the drug must be carried out directly into the joint cavity, otherwise, local soreness may develop.

Adant should be used with caution in patients with a aggravated allergic history and in patients with impaired liver function..

Appointment for elderly patients: the drug should be used with caution, as in the elderly, many physiological functions of the body are reduced.

Unnecessarily. the safety of the drug when administered to children has not been studied, then it should be used with caution..

Adant should be used with caution in patients with hepatic impairment..

Despite, that in the course of preclinical studies the teratogenic properties of the drug were not detected, its safety in pregnant women has not been studied.

Therefore, pregnant women, or suspected pregnancy, the drug should be used with caution.

Sodium hyaluronate is secreted in animal milk, therefore, it is recommended to stop breastfeeding for the duration of the drug use.

Adant: interactions with other drugs and alcohol

Do not mix with quaternary ammonium salts, including benzalkonium chloride, or with chlorhexidine, due to the development of precipitation.

Adant: composition and properties

One syringe (2.5 ml) the drug Adant contains 25 mg sodium hyaluronate.

Adant: pharmachologic effect

Hualuronic acid has the following physical properties, which make it possible to use this substance as a substitute for synovial fluid disturbed by the inflammatory process.

Thus, restoring the physical characteristics of the joint fluid, hyaluronic acid increases mobility and reduces joint pain, affected by osteoarthritis or periarthritis.

Besides, the drug induces the synthesis of high molecular weight hyaluronic acid, similar in structure to "regular" hyaluronic acid, in synovial joints, affected by a chronic degenerative or inflammatory process.

Without this stimulus, the molecular weight of hyaluronic acid synthesized by synoviocytes is below normal..

This mechanism of action combines the prolonged clinical effect of sodium hyaluronate, in which 10 times greater than the effect from the calculation of intra-articular clearance and metabolism.

Intra-articular administration of the drug Adant improves the functioning of the joints, relieves pain, caused by osteoarthritis of the knee and shoulder joints.

Adant improves joint mobility and normalizes the composition of synovial fluid. Besides, Adant is indicated for administration into the carpometacarpal joint in patients, suffering from rhizarthrosis.

Adant: release form

Solution for injection, 10 mg / ml 2,5 ml in filled syringes No. 1

Adant: storage conditions

At 1-30°C or freeze. Restrict access for children. Shelf life - three years.

Adant: general information

• Sales form: on prescription
• Current in-about: Zinc hyaluronate