Aspekard - instructions for use of the drug, structure, Contraindications

Acpekard (Aspecard) – antiplatelet drug.

Acpekard: pharmachologic effect

Active ingredient Aspekard – acetylsalicylic acid has the following functions:

• Preventing blood clots
• Analgesic effect
• Minimize body inflammation
• Decreased core body temperature

Acetylsalicylic acid also inhibits the action of cyclooxygenase (Splendor-1) is a group of enzymes, which is responsible for the production of thromboxanes, prostaglandins and cyclin. For this reason, there are violations in the synthesis of these substances in the body..

A decrease in the production of prostaglandins causes a decrease in their sensitization to nerve endings and neurons to pain mediators., and also the systematic influence of prostaglandins on the thermoregulatory center decreases. The anti-temperature effect of acetylsalicylic acid is caused by a violation of the production of thromboxane A2 in platelets., which is responsible for the production of new platelets and their state changes.

Acetylsalicylic acids contained in the drug Aspekard are quickly and completely absorbed through the organs of the gastrointestinal tract.

The maximum level of acetylsalicylic acid in the blood occurs after 10-20 minutes after taking a dose of the drug.

The level of binding of blood plasma and proteins is equal to the level of acetylsalicylic acid (49-70%). ½ of the taken dose of the drug breaks down when passing through the liver. Processing products of acetylsalicylic acid are excreted through the kidneys. The time frame for partial elimination of a substance is 20 minutes. With an increase in the dose of Aspecard, the elimination time increases. The active substance has the ability to penetrate into breast milk with the help of cerebrospinal and synovial fluid and the blood-brain barrier.

Acpekard: testimony

Aspekard is used as an antiplatelet drug, which inhibits platelet aggregation, which effectively helps with different stages of angina pectoris and acute myocardial infarction. Besides, the drug is used in the prevention of the following diseases:

• Thrombosis of the coronary arteries
• Thrombosis and embolism after operations on the vascular-cardiac system (percutaneous transluminal coronary angioplasty, coronary artery bypass grafting)
• Recurrent myocardial infarction
• Ischemic stroke
• Cerebrovascular accident
• Primary myocardial infarction in patients with factors, which can lead to cardiovascular complications (hypertension, diabetes, hyperlipidemia, obesity, age factor, nicotine addiction, etc.)

Also used to relieve pain in a number of conditions.:

• Febrile states (flu, cold)
• Heat
• Joint pain
• Chronic and acute inflammatory diseases of the bones (rheumatoid arthritis, osteoarthritis and ankylosing spondylitis)

Acpekard: mode of application

The recommended daily allowance of Aspekard is 1 tablets - 1 once a day after meals. The tablet should be taken with water or milk, to reduce the irritant effect on the digestive system.

The duration of the course is from 2 months before 2 years and is determined individually by the attending physician according to the treatment plan and anamnesis.

The dose may be increased to 2-3 tablets per day for the prevention of myocardial infarction. The preventive course lasts on average 2-3 of the month. The maximum rate per day of Aspecard is 300 mg.

Has no effect on driving vehicles and heavy machinery.

The drug is easily excreted through the kidneys during the day.

Acpekard: side effects

Adverse reactions of the gastrointestinal tract and liver: rarely nausea, indigestion, vomiting, pain or discomfort in the epigastric region, bleeding in the stomach, erosion of the walls of the stomach, gastric ulcer, disorders of the gastrointestinal tract, liver dysfunction.

Adverse reactions of the central nervous system: prolonged use may cause dizziness, headache, tinnitus.

Adverse reactions of the circulatory system: very rarely signs of anemia, hemorrhagic syndrome.

Adverse reactions of hemostasis: in some cases, the appearance of hemorrhagic syndrome, thrombocytopenia.

Adverse reactions of metabolism: possible hypoglycemia.

Adverse reactions excretory organs: violation of kidney function.

Allergic reactions to the components of the composition: rash on the skin, itch, hives, bronchospasm.

Aspecard should be used with caution in patients with gastric ulcers., severe liver disease, kidney and intestinal tract. Also, if the patient has an allergic reaction to drugs, with chronic bronchial asthma and parallel passage of a course of anticoagulants (heparin and coumarin, and the like.) Talk to your doctor.

Aspecard may cause an allergic reaction in the form of bronchial asthma in patients with the following types of diseases:

• Allergy (traheobronhit, allergic rhinosinusitis, pollen disease, laringit)
• Hypersensitivity to non-steroidal anti-inflammatory drugs
• Infectious diseases of the respiratory system

When taking high doses of the drug or during a long duration of the course of taking this drug, control by the attending doctor is necessary for the following indicators of the patient's body:

• Analysis of feces for blood content
• Platelet level
• The level of urea and the presence of blood in the urine
• Coagulation diagnostics

Before undergoing surgical or dental interventions, it is necessary to warn the doctor about taking this medicine..

Acpekard: Contraindications

Aspecard is contraindicated in the following diseases:

• hemophilia
• Decreased tendency to bleed
• Decreased blood coagulation
• Hemorrhagic diathesis
• Exacerbation of stomach ulcer
• Kidney and liver dysfunction

Also forbidden for use by children under the age of 14 years and women during pregnancy and lactation. Due to the results of the study of the effect of acetylsalicylic acid on the fetus. During it, the likelihood of development of inhibition of mental operations in newborns was discovered.. There is also a chance of miscarriage while taking the drug..

For children and adolescents, the course of the drug is prescribed for 2 weeks by the attending physician, with such diseases:

• Pain syndrome of mild and moderate severity
• Infectious-allergic myocarditis
• Infectious fever of the inflammatory type (constant, exhausting, intermittent, atypical, etc.)

Besides, not recommended for patients with developed sensitivity to aspirin and similar salicylates.

Acpekard: interaction with other drugs

Aspecard enhances the effect of drugs such as:

• Nonsteroidal anti-inflammatory and antirheumatic drugs
• Triiodothyronine
• Antykoahulyantы
• Methotrexate
• Oral hypoglycemic drugs containing sulfonylurea

Aspecard prevents the action of uricosuric drugs (etamid, sulfinpirazon, probenecid, etc.), diuretics (furosemid, spironolactone), antihypertensive drugs (tenor, captopril, anaprilin, etc.).

With prolonged uncontrolled use of Aspecard in parallel with analgesics, kidney dysfunction or, in rare cases, nephropathy may occur..

Causes a violation of the mucosa of the gastrointestinal tract when combined with glucocorticosteroids and ethanol. May increase blood levels of barbiturates, lithium salts and digoxin.

Aspekard is prohibited for use together with antacids.

Acpekard: overdose

In the early stages of an overdose the following symptoms occur: dizziness, nausea, vomiting, noise in ears, headache. Children and older people may also have trouble seeing and hearing clearly..

In the later stages of an overdose, the following symptoms occur: brain dysfunction, partial loss of consciousness, painful weakness, drowsiness, convulsions, choking and shortness of breath.

Besides, in cases of overdose was recorded:

• Severe dehydration
• accelerated breathing
• Cases of falling into a coma
• Lowering blood sugar
• Hyperthermia
• Increasing the acidity of urine

Dose Aspekard, fatal: for children – 3 g, for adults – better 10 g.

The antidote for an overdose of this drug is an infusion solution of sodium lactate., sodium bicarbonate or sodium citrate. The selection of a suitable antidote is carried out taking into account the acid-base level and electrolyte balance.

Acpekard: structure

Active substance:

1 Aspecard tablet contains 0,1 g acetylsalicylic acid;

Excipients:

• Croscarmellose sodium
• Microcrystalline cellulose
• Stearic acid
• Silicon dioxide colloidal

Product form:

white tablets, top and bottom surfaces are flat, the edges of the surfaces are beveled. Bundle on 100 mg № 120 (12x10) in blisters, № 100 in containers.

Storage conditions:

Store Aspecard in a dry place., protected from light, at room temperature (+25 ° C). Keep out of the reach of children. Shelf life 3 year closed.

Acpekard: general information

• Sales form: over-the-counter
• Current in-about: Acetylsalicylic acid
• Manufacturer: Stirolbiopharm, LTD, Donetsk region., Gorlovka, Ukraine
• Farm. Group: Anti-inflammatory drugs of various groups