Abistan - instructions for use of the medicine, structure, Contraindications

Abistan is a drug for complex therapy related to clobetasol propinate-glucocorticosteroids. This medicine has a catabolic effect on the following types of tissues:

• lymphoid;
• connecting;
• fatty;
• muscular.

Besides, Abistan has the following medicinal properties:

• anti-inflammatory;
• antiallergic;
• immunosuppressive;
• reduces the production of prostaglandins in the body;
• reduces the amount of leukotrienes.

Abistan: indications and dosage

Abistan ointment is indicated for use in such diseases:

• upper skin fungus (keratomycosis, ringworm, candidiasis, sporotrichosis, deep coccidioid mycosis);
• bacterial superinfection on the skin;
• infections after cryotherapy - rejuvenation with cold chemicals: carbonic acid snow and or liquid nitrogen.

Skin bacterial superinfections include:

• acute/chronic eczema - skin disease, which is characterized by rashes and itching with possible relapses;
• гиперкератоз – ороговение кожных участков или всего кожного покрова из-за усиленного деления клеток эпидермиса;
• acute contact dermatitis - skin disease, that develops in response to some stimulus (allergen);
• chronic hyperkeratic psoriasis (psoriasis)
• hypertrophic lichen planus
• pemphigoid localized areas of scars (bullous pemphigoid (nonacantholytic pemphigus), scarring pemphigoid (pemphigus eye) and benign non-acantholytic pemphigus of the oral mucosa).
• pretibial myxedema is an endocrine disease, related to hormonal imbalance, produced by the thyroid gland, namely with thyrotoxicosis.
• keloid scars - tumor-like proliferation of coarse fibrous connective tissue of the skin. Most often genetically determined.

The drug Abistan is applied to the site of the lesion. The cream should be applied in a thin layer on the desired area of ​​the skin. 1-2 once a day. Can also be applied under an occlusive dressing 1 once a day.

Overlay technique occlusive dressing next: a water- and airtight material is placed on the wound surface and the surrounding skin area with a radius of 5-10 cm, eg, synthetic film or rubberized fabric, which is fixed with an ordinary bandage.

You can also use Abistan cream in the form of applications. 1 once a day.

The doctor prescribes the duration of the course of treatment for each patient individually..

Abistan: overdose

Acute overdose with topical application of Abistan has not been recorded..

With prolonged or excessive use of local drugs, inhibition of pituitary-adrenal function is possible with the development of secondary adrenal insufficiency and the appearance of symptoms of hypercortisolism, including Cushing's disease.

For treatment, symptomatic therapy is prescribed. The symptoms of acute hypercortisolism are usually easily treatable.. If necessary, correct electrolyte balance. In case of chronic toxic action, gradual withdrawal of the drug is recommended..

In case of overgrowth of resistant microorganisms (resistant strains of viruses to the action of various antibiotic agents) recommend stopping treatment with Abistan and prescribing the necessary antibiotic therapy.

Abistan: use during pregnancy or lactation

Abistan should not be used by women during pregnancy and lactation..

Use of the drug in children

The drug is contraindicated in children under 12 years.

Abistan: side effects

Adverse reactions are rare.

Local reactions include:

• burning sensation,
• эritema,
• exudation,
• pigmentation disorders (gipopigmentatsiya) and fast.

With prolonged use of the drug Abistan possible:

• striae formation,
• skin atrophy,
• Telangiectasia,
• itching,
• rashes.

Adverse Reactions, caused by gentamicin (usually do not require discontinuation of treatment):

• hyperemia,
• itch.

Adverse reactions due to the presence of miconazole in the preparation:

• эritema (is redness of certain areas of the skin, which is caused by excessive filling of the skin capillaries with blood),
• burning sensation,
• blistering,
• peeling,
• local swelling,
• itch,
• hives,
• general skin irritation.

Abistan: Contraindications

Abistan cream is prohibited for use under such conditions:

• developed hypersensitivity to the chemical composition of the drug;
• with rosacea (rosacea);
• post-vaccination reaction;
• enable vetryanaya (acute viral illness, characterized by fever and papulovesicular (nodular-vesicular) rash);
• drug dermatitis (inflammatory skin changes, arising from external, internal or parenteral use of a drug);
• cutaneous manifestations of syphilis (hard chancre - formation before 1 cm with a bluish-reddish color);
• lupus (penetration into the skin of Mycobacterium tuberculosis);
• children's dermatosis.

There is no information regarding the safety of using Abistan cream during pregnancy / lactation..

Interaction with other drugs and alcohol

It is not recommended to drink alcohol while using the drug Abistan.

Abistan: composition and properties

Structure

Abistan is part of:

• clobetasol propionate;
• gentamicin sulfate;
• miconazole nitrate.

Product form

Cream in a tube, 10 g.

Abistan: pharmachologic effect

Abistan is a cream of complex action, related to clobetasol propionate - glucocorticosteroids. Has a catabolic effect on body tissues:

• lymphoid;
• connecting;
• fatty;
• muscular.

Has a number of healing properties:

• anti-inflammatory;
• antiallergic;
• immunosuppressive.

It also reduces the production of prostaglandins and leukotrienes..

When applied topically, it removes in a short time:

• swelling;
• itching;
• hyperemia - excessive overflow of blood vessels of the circulatory system, located in a specific organ or area of ​​the body.

Gentamicin sulfate is an antibacterial agent of the aminoglycoside group., which has a combined bactericidal effect. Miconazole nitrate has a fungicidal effect on the following fungal pathogens:

• yeast and yeast-like fungi (Candida albicans)
• dermatophyte (Trichophyton mentagrophytes, Trichophyton rubrum, Microspores dog, Epidermophyton floccosum)
• pathogenic fungi (Aspergillus niger, Malassezia furfur, Penicillum crustaceum and others)

Miconazole reduces the production of substances, which are responsible for the formation of fungi and violate the protective functions of fungal membranes, namely:

• ergosterol;
• triglycerides;
• fosfolypydov.

Has little hyperosmolar activity, what helps it to have an anti-exudative effect.

Abistan: pharmacokinetics

Clobetasol propionate is absorbed through intact skin no more than 5% from the dose to the skin surface. The presence of an inflammatory process slightly increases the penetration of clobetasol into the stratum corneum..

Gentamicin is poorly absorbed. Associated with the plasma protein (to 10%), half-life is 2-4 o'clock. Do not metabolized. Write mainly with urine. Miconazole, when applied to the skin, is practically not absorbed and does not enter the systemic circulation..

Storage conditionsAt a temperature not higher than +25°C. Restrict access for children. Shelf life 2 year.

Abistan: general information

• Sales form: over-the-counter
• Current in-about: Clobetasole
• Farm. Group: Decongestants and other topical preparations for diseases of the nasal cavity. Corticosteroids.