Pindolol

When ATH:
C07AA03

Characteristic.

White or off-white powder;. It is soluble in organic solvents and aqueous solutions of acids.

Pharmacological action.
Gipotenzivnoe, antianginalnoe, antiarrhythmic.

Application.

Arterial hypertension, angina, supraventricular arrhythmias (sinus tachycardia, tachysystolic atrial fibrillation, arrythmia), hyperkinetic cardiac syndrome, gipertroficheskaya cardiomyopathy, tremor (essencialny, senile), mitral valve prolapse.

Contraindications.

Hypersensitivity, bronchial asthma, severe chronic heart failure, pulmonary heart, AV блокада II и III степени, hypotension (Sad below 100 mm Hg. Art.), vыrazhennaya bradycardia (less than 45-50 beats. / min), sick sinus syndrome, pregnancy, lactation.

Restrictions apply.

Heart failure, AV блокада I степени, of the liver and kidneys (incl. history), a tendency to bronchospasm, incl. chronic bronchitis, emphysema, acute phase of myocardial infarction, disorders of peripheral blood circulation, hyperthyroidism, depression, psoriasis, diabetes, gipoglikemiâ, childhood (safety and effectiveness in children have not identified).

Pregnancy and breast-feeding.

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects.

From the nervous system and sensory organs: insomnia (10%), dizziness (9%), fatiguability (8%), anxiety (7%), increase in the number or the appearance of strange dreams (5%), weakness (4%), paresthesia (3%), disorientation in time and space, depression, kratkovremennaya amnesia, emotional lability, hallucinations, vision changes, discomfort in the eyes.

With the genitourinary system: swelling (6%), less than 2% случаев — импотенция, thamuria.

From the digestive tract: dyspepsia (4%), nausea (5%), diarrhea (2%), vomiting (2%), ishemicheskiy colitis, mezenteryalnoy artery thrombosis.

From the respiratory system: breathlessness (5%), chest pain (3%), laringo- and bronchospasm, respiratory distress syndrome.

Cardio-vascular system and blood (hematopoiesis, hemostasis): less than 1% случаев — сердцебиение, heart failure, bradycardia, tachycardia, OF блокада, gipotenziya, syncope, intermittent claudication, cold extremities, agranulocytosis, thrombocytopenia, purpura.

On the part of the musculoskeletal system: arthralgia (7%), myalgia (10%), muscle cramps (3%).

Other: hyperhidrosis, erythematous rash, hives, obratimaya alopecia, weight gain.

Cooperation.

It increases the likelihood of violations of all functions of the heart and the risk of hypotension in the background amiodarone, diltiazema, verapamil (especially when on / in), drugs quinidine series. The joint appointment with clonidine possible dysregulation of blood pressure, with agonists (amfetaminы, ephedrine, epinephrine, norepinephrine, Phenylephrine, Pseudoephedrine) — повышение риска гипертензии и брадикардии, с резерпином — вероятности AV блокады, с фенотиазинами — усиление гипотензии, с НПВС — ослабление гипотензивного эффекта; cimetidine increases the plasma concentration. Appointment to the background beta-adrenoceptor stimulants and xanthine derivatives leads to mutual suppression effects. Incompatible with MAO inhibitors (mutual weakening effects). Lidocaine inhibits metabolism in the liver, Increases in blood thioridazine, potentiates the effect of non-depolarizing muscle relaxants.

Overdose.

Symptoms: bradycardia, gipotenziya, heart failure, bronchospasm.

Treatment: gastric lavage and appointment of adsorbents, monitoring vital functions, simptomaticheskaya therapy: при выраженной брадикардии — атропин; сердечной недостаточности — сердечные гликозиды, Diuretic, glucagon, гипотензии — вазопрессоры (epinephrine and others.), under the control of blood pressure; бронхоспазме — изопротеренол или производные теофиллина; AV блокаде — трансвенозная стимуляция; sedativnaya therapy (diazepam).

Dosing and Administration.

Inside, in one or two steps (morning and afternoon). Dose picked individually. Hypertension - By 5 mg 1-2 times a day, при необходимости через 1–2 нед дозу постепенно увеличивают на 10 mg / day (with two- week intervals) до максимальной — 60 mg / day; maintenance dose - 5 mg 1 once a day. Angina - By 5 mg 3 once a day; through 1 нед возможно повышение до 10 mg 3 fold or 15 mg 2 once a day (у пожилых людей — 1 time); the maximum dose - 40 mg / day. Irregular heartbeat — 15–30 мг/сут, hyperkinetic cardiac syndrome — 7,5–20 мг в 1 or 2 admission.

Precautions.

It is necessary to bear in mind the possibility of masking the clinical manifestations of hyperthyroidism (tachycardia) and hypoglycemia (tachycardia, changes in blood pressure). It increases the severity and duration of anaphylactic reactions to allergens. Perhaps the increased severity of hypersensitivity reactions and the lack of effect of conventional doses of epinephrine with aggravated allergic history. When pheochromocytoma should not be given without the introduction of alpha-blockers. When combined with alcohol can orthostatic collapse. It reduces the compensatory cardiovascular reactions in response to the use of general anesthetics and iodine-containing contrast agents. A few days before surgery with general anesthesia is necessary to cancel or select an anesthetic with the least negative inotropic effects. In order to prevent the development of withdrawal symptoms gradually stopped for about 2 Sun. Do not interrupt or finish treatment without consulting your doctor. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.

Cautions.

You can change the parameters for laboratory tests.

Cooperation