Active material: Acetylsalicylic acid
When ATH: N02BA01
CCF: NSAIDs
ICD-10 codes (testimony): G43, K08.8, M25.5, M54.1, M79.1, M79.2, N94.4, N94.5, R51, R52.0, R52.2
When CSF: 05.01.01.01
Manufacturer: BRISTOL-MYERS SQUIBB (France)
◊ Effervescent tablets white, round, flat, with beveled edges and scored on one side; when dissolved in water is observed effervescence.
| 1 tab. | |
| acetylsalicylic acid | 500 mg |
Excipients: Citric acid anhydrous, anhydrous sodium carbonate,, natriya carbonate, sodium citrate, anhydrous, Aspartame, povidone, krospovydon, Orange flavoring natural.
4 PC. – стрипы (4) – пачки картонные.
4 PC. – стрипы (25) – пачки картонные.
NSAIDs. Anti-inflammatory, analgesic and antipyretic effect, associated with suppressing Cox-1 and Cox-2, regulating the synthesis of prostaglandins. Decreases agregatia, adgezivnosti platelets and blood clots by suppressing synthesis of thromboxane A2 in platelets. Antiagregantnyj effect persists for 7 days after a single admission (more pronounced in men, than in women).
Dissolving in water, Tablet Upsarina Upsa forms a buffer solution, that after taking the drug supports the existing substance in dissolved form, not letting them in contact with acidic stomach Wednesday to move back into the nerastvorennuû form and precipitate in the form of particulate matter on his walls. The result is a more rapid and complete absorption of the drug, as well as his better portability than conventional tablets of acetylsalicylic acid.
Data for farmakokinetike Upsarin Upsa is not provided.
-moderately or weakly expressed pain syndrome in adults of different origins: headache (incl. associated with alcohol withdrawal symptoms), toothache, migraine, neuralgia, thoracic radicular syndrome, muscle and joint pain, algomenorrhea;
- Fever with colds and other infectious and inflammatory diseases (in adults and children older than 15 years).
For the reception drug should dissolve the pill/tablet in a glass of (200 ml) water or juice.
The drug is prescribed inside adults and children over 15 years by 500 mg (1 tab.) to 6 time / day. In the context of strong pain and high temperature single dose can be 1 g (2 tab.). The maximum daily dose - 3 g (6 tab.).
Elderly patients appoint 500 mg (1 tab.) to 4 time / day. The maximum daily dose - 2 g (4 tab.).
The interval between meals preparation shall be not less than 4 no. Regular adherence to the drug avoids a sharp increase in temperature and decrease the intensity of the pain syndrome
Length of treatment (without consulting your doctor) should not exceed 5 days in the appointment as a means of pain relief and more 3 дней – в качестве жаропонижающего средства
Allergic reactions: редко – кожная сыпь, bronchospasm, angioedema, формирование на основе гаптенового механизма “аспириновой триады” (a combination of asthma, recurrent nasal polyposis, and paranasal sinuses, and intolerances acetylsalicylic acid and drugs pirazolonovogo stimulants).
From the digestive system: rarely - nausea, vomiting, epigastric pain, diarrhea, gastrointestinal bleeding (рвота типа “кофейной гущи”, black tarry stools), decreased appetite, increase in liver transaminases.
From the urinary system: редко – нарушение функции почек.
From the hematopoietic system: a rare - thrombocytopenia, anemia, leukopenia, giperʙiliruʙinemija.
From the blood coagulation system: редко – геморрагический синдром (nose bleed, krovotochivosty right), increase blood clotting time.
At the recommended doses, the drug is generally well tolerated.
Patients should be warned about, that in the case of adverse reactions should stop taking the drug immediately and inform the treating physician.
- Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, gastrointestinal bleeding;
- Expressed human liver;
- Expressed by the human kidney;
— “аспириновая” астма;
- Hemorrhagic diathesis (hemophilia, von Willebrand disease, teleangioэktaziya, gipoprotrombinemii, thrombocytopenia, trombotsitopenicheskaya purpura);
— rasslaivaûŝaâ aortic aneurysm;
- Portal hypertension;
- Vitamin K deficiency;
- Deficiency of glucose-6-fosfatdegidrogenazы, phenylketonuria;
- I and III trimesters of pregnancy;
- Lactation (breast-feeding);
- Children under the age of 15 years with acute respiratory diseases, caused by viral infections, because of the risk of Reye's syndrome (acute encephalopathy and fatty degeneration of the liver with acute development of hepatic failure);
- Hypersensitivity to the drug;
-hypersensitivity to other NSAIDS.
FROM caution the drug should be used with hyperuricemia, uratnom nefrolitiaze, gout, stomach ulcers and/or duodenal ulcer (history), decompensated heart failure.
The drug is contraindicated in the I and III trimestrah pregnancy.
If necessary, use during lactation should stop breastfeeding.
Acetylsalicylic acid reduces uric acid from the body, that can cause acute gout attack prone patients.
With long-term use drugs should periodically hemogram and occult blood feces analysis, monitor the functional State of the liver.
Before surgery, to reduce bleeding during surgery and post-surgical period, admission drug should be abolished for 5-7 days and notify the physician.
Patients, observe the salt-free or low salt diet, should be considered, each tablet of the drug contains 388.5 mg (16.9 mèkv) sodium.
Use in Pediatrics
Children cannot prescribe drugs, containing acetylsalicylic acid, because in case of a virus infection increases the risk of getting Reye's syndrome. Reye-syndrome symptoms are prolonged vomiting, acute encephalopathy, enlargement of the liver.
Symptoms: in the initial stage of poisoning develop symptoms of CENTRAL NERVOUS SYSTEM excitation , dizziness, Strong headache, hearing loss, blurred vision, nausea, vomiting, increased respiration. Later comes the oppression of consciousness until coma, respiratory insufficiency, violations vodno-elektrolitnogo Exchange.
Treatment: It should be cause vomiting or lavage stomach, designate activated carbon and laxative. Treatment should be carried out in a specialized branch
Acetylsalicylic acid increases the toxicity of methotrexate, effects of narcotic analgesics, other NSAIDs, oral hypoglycemic drugs, geparina, anticoagulants, thrombolysis and platelet aggregation inhibitors, sulfonamides (incl. co-trimoxazole), triiodothyronine.
Acetylsalicylic acid reduces the toxicity of urikozuričeskih drugs (ʙenzʙromaron, sulfinpirazon), and gipotenziveh funds dioretikov (spironolactone, furosemid).
GCS, ethanol and etanolsodergaszczye products increase the deleterious effect of acetylsalicylic acid on the mucous membrane of the STOMACH, increase the risk of gastrointestinal bleeding.
Acetylsalicylic acid increases the concentration of Digoxin, barbiturates and drugs lithium in plasma.
Antacids, containing magnesium and/or aluminum hydroxide, slow down and reduce absorption of acetylsalicylic acid
The drug is resolved to application as an agent Valium holidays.
The drug should be stored out of reach of children, dry, inaccessible to children at temperature not exceeding 30 ° C. Shelf life - 3 year.
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