TROPYKAMYD

Active material: Tropykamyd
When ATH: S01FA06
CCF: M-cholinergic receptor blocker for local application in ophthalmology (midriatik)
ICD-10 codes (testimony): H10.2, H10.4, Z01.0, Z29.8, Z51.4
When CSF: 26.02.01
Manufacturer: WARSAW PHARMACEUTICAL WORK POLFA S.A. (Poland)

Pharmaceutical form, composition and packaging

Eye drops 0.5% Colorless, clear.

Excipients: sodium chloride, disodium edetate, benzalkonium chloride, hydrochloric acid, water d / and.

5 ml – dropper bottle plastic (1) – packs cardboard.
5 ml – dropper bottle plastic (2) – packs cardboard.

Eye drops 1% Colorless, clear.

Excipients: sodium chloride, disodium edetate, benzalkonium chloride, hydrochloric acid, water d / and.

5 ml – plastic bottles (1) – packs cardboard.
5 ml – plastic bottles (2) – packs cardboard.

Pharmacological action

Midriatik. Does m-cholinergic receptors of the sphincter of the iris and ciliary muscle, quickly and briefly dilates the pupil and paralyzes the accommodation of. Pupil dilation begins 5-10 minutes after a single instillation of drug into the conjunctival sac, reaches through 15-20 minutes and persists for 1 h at instillation 0.5% droplets and 2 no – instillation 1% drops. Full recovery takes place via the pupil size 3-5 no.

The maximum accommodation paralysis after instillation 1% tropicamide drops 2 times at intervals 5 It occurs within minutes 25 minutes and lasts for about 30 m. Full recovery takes about a 3 no.

Pharmacokinetics

After instillation of the drug in the conjunctival sac tropicamide marginally exposed systemic absorption (especially in children and the elderly).

Testimony

With diagnostic purposes:

- If necessary, mydriasis in the study of the fundus and evaluation of the lens;

- If necessary, paralysis of accommodation in the investigation of refraction.

Before the surgery:

- Surgery of the lens;

- Retinal laser therapy;

- Surgery of the retina and vitreous.

Therapeutic purposes:

- As a component of the complex therapy of inflammatory diseases of the eye and in the postoperative period for the prevention of adhesions.

Dosage regimen

The drug is instilled into the conjunctival sac.

To mydriasis buried 1 drop 1% or 2 drops 0.5% solution (from 5 min intervals). Through 10 min can be performed ophthalmoscopy. With little effect (very high light intensity, Use the back for breaking adhesions) can be used together with phenylephrine.

To achieve paralysis of accommodation (the study of refraction) buried 1 drop 1% tropicamide solution 6 time intervals 6-12 m. Examination is preferably carried out during 25-50 minutes after the last instillation of the drug.

In infants and children up to 6 years Only apply it 0.5% eye drops.

Premature babies have been observed in some cases, systemic anticholinergic effects tropicamide, aggravated with repeated use. These adverse effects can be prevented without reducing efficiency by prescription drug dilution isotonic sodium chloride solution (1:1).

During instillation of the drug should be lightly press the tear ducts, to limit the excessive absorption of tropicamide and prevent systemic anticholinergic effect of the drug.

Dosage regimen therapeutic set individually (depending on the condition of the patient).

Side effect

On the part of the organ of vision: increased intraocular pressure; violation of visual acuity; photophobia.

CNS: sometimes – psychotic symptoms, misconduct (especially in children and adolescents); headache (adult).

Cardio-vascular system: symptoms of circulatory and respiratory insufficiency (especially in children and adolescents); tachycardia (adult).

Other: dry mouth, allergic reactions.

Contraindications

- Glaucoma (especially the closure and the mixed primary);

- Hypersensitivity to the drug.

Pregnancy and lactation

Application tropicamide during pregnancy is possible only in cases, when the intended benefits to the mother outweighs the potential risk to the fetus.

It should be used with caution during lactation (breast-feeding).

Cautions

Before applying for tropicamide mydriasis before examining the fundus of the patient is necessary to conduct a survey to identify possible angle-closure glaucoma (update history, to assess the depth of the anterior chamber, gonioscopy), tk. possible acute attacks of glaucoma after treatment.

Before using tropicamide for diagnostic purposes should notify the patient or attendant about temporary visual disturbances and photophobia.

Do not touch the tip of the dropper, tk. this may cause contamination of the vial.

Before using tropicamide necessary to remove soft contact lenses. Set them again can be no earlier than 30 minutes after instillation of the drug.

Use in Pediatrics

Before using tropicamide for diagnostic purposes in children should be warned attendant about temporary visual disturbances and photophobia.

Use of the drug in infants and young children can cause disorders of the central nervous system.

Effects on ability to drive vehicles and management mechanisms

In applying tropicamide should not drive and use machines.

Overdose

Currently, cases of drug overdose Tropikamid (with instillation into the conjunctival sac) not reported.

Drug Interactions

Concomitant use of anticholinergics and histamine H₁-receptors, phenothiazine, tricyclic antidepressants, prokaynamyda, xinidina, MAO inhibitors, benzodiazepines and antipsychotics mutually reinforce each other's action.

Cycloplegia, called tropicamide, enhanced by its simultaneous use with sympathomimetic agents and attenuated while the use of parasympathomimetics.

With simultaneous application of tropicamide and nitrates, nitride, basifying drugs, dizopiramida, GCS and haloperidol may increase intraocular pressure in angle-closure glaucoma accompanying.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

The drug should be protected from light and away from children at a temperature of 15 ° to 25 ° C. Shelf life – 3 year.

After opening the bottle shelf life – 4 of the week.