Terizidon

When ATH:
J04AK03

Pharmacological action

Bacteriostatic broad spectrum antibiotic, активен в отношении Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium, and также Staphylococcus aureus и Staphylococcus epidermidis.

Also sensitive: Enterococcus faecalis, Escherichia coli, Citrobacter spp., Enterobacter spp., Morganella morganii, Klebsiella pneumoniae и Pseudomonas aeruginosa.

The development of secondary resistance is rare. Cross-resistance with other anti-TB drugs is not observed.

Pharmacokinetics

Absorption from the gastrointestinal tract – 70-90% (eating does not affect the rate of absorption). The time to reach Cmax – 2-3 no. Effective Cmin: for Mycobacterium tuberculosis – 10-40 mg / l, for staphylococci – 8-32 mg / l, for Gram-negative bacteria (have clinical significance) – 20-250 mg / l.

It is well distributed in tissues and body fluids (lungs, bile, ascites fluid, pleural effusion, joint fluid, lymphatic, wetness).

It penetrates into the CSF (80-100% concentration in serum), higher concentration in CSF is created when the inflammatory changes of the meninges.

Metabolized slightly.

T1 / 2 – 21 no. Report the news (in unchanged form – 60-70%), kishechnika (a minor amount in unchanged form and as metabolites).

Testimony

Tuberculosis different shapes and locations in the complex therapy-resistant forms of the disease.

Dosage regimen

Inside, regardless of the meal: adults and children over 14 age and body weight of less than 60 kg – by 300 mg 2 (600 mg /); body weight 60-80 kg – by 300 mg 3 (900 mg /). Adults weighing more than 80 kg – by 600 mg 2 (1200 mg /). Take for 3-4 Months.

At least QC 30 ml / min the dose and dosing frequency lower.

Side effect

From the nervous system: headache, dizziness, hypererethism, tremor, insomnia, feeling of intoxication; in a few cases – epileptimorfnye seizures, depression, psychosis.

From the digestive system: rarely – abdominal pain, flatulence, diarrhea.

Allergic reactions.

Contraindications

Hypersensitivity (incl. to cycloserine).

Organic diseases of the central nervous system (incl. I degree).

Epilepsy.

Mental disorders.

Alcoholism.

Pregnancy.

Lactation.

Childhood (to 14 years).

C care: advanced age, sedrechnaya chronic failure, CRF.

Pregnancy and lactation

Contraindications: pregnancy; lactation.

Application for violations of renal function

C care: CRF.

At least QC 30 ml / min the dose and dosing frequency lower.

Cautions

Terizidone cyanocobalamin deficiency can cause and / or folic acid, necessary to carry out an appropriate examination and treatment.

It should be on a monthly basis to monitor blood and urine, liver function (GOLD, ACT, bilirubin).

You should avoid the use of ethanol, tk. simultaneous reception terizidone increases the incidence of side effects (until the development of seizures).

Due to the possibility of adverse reactions of the nervous system (depression, behavior change), need to monitor the mental status of the patient.

Effects on ability to drive vehicles and management mechanisms

During the period of treatment should refrain from driving vehicles and Occupation potentially hazardous activities, require high concentration and speed of psychomotor reactions.

Overdose

Symptoms: increased neurotoxicity (incl. epileptiform seizures), dysfunction of the gastrointestinal tract.

Treatment: symptomatic, Activated carbon, anticonvulsants, sedative drugs. Hemodialysis is effective.

Drug Interactions

Ethanol increases the risk of seizures.

In an application with ethionamide increases the risk of side effects from the CNS (especially seizures).

The simultaneous use of isoniazid increases the incidence of dizziness, drowsiness.