TERAFLYu S

Active material: Benzoksoniya chloride, Lidokain
When ATH: R02AA20
CCF: The preparation with antimicrobial and Valium action for local application in an ENT-practice and stomatology
ICD-10 codes (testimony): J02, J03, J04, J31, J35.0, J37, K05, K12
When CSF: 24.01.07.01
Manufacturer: NOVARTIS CONSUMER HEALTH S.A. (Switzerland)

Pharmaceutical form, composition and packaging

◊ Lozenges round, lenticular, white with a yellowish tinge, with the logo of the company Zyma (two triangles, located opposite each other with a certain offset) on one side and a code “OR” – on the back side, with orange scent.

Excipients: sorbitol (1 g, that respectively. about 17 kJ / kcal 4), microcrystalline cellulose, macrogol 6000, corn starch, sodium saccharin, sodium chloride, lemon acid, magnesium stearate, orange flavor.

8 PC. – blisters (1) – packs cardboard.
8 PC. – blisters (2) – packs cardboard.
8 PC. – blisters (3) – packs cardboard.

◊ Spray for topical use as a clear, colorless solution with the smell of mint.

Excipients: ethanol, peppermint oil, menthol, glycerol, hydrochloric acid, Purified water.

30 ml – bottles of high density polyethylene (1) complete with nozzle spray – packs cardboard.

Pharmacological action

Antiseptic preparation for local application in an ENT-practice. It is a quaternary ammonium salt: N-бензил N-додецил N, N-ди(2-hydroxyethyl) Ammonium chloride. Due to the structure of the cation has membranotropic activity and has a pronounced antibacterial effect against gram-positive and, less, Gram-negative bacteria. Benzoksony also has antifungal and antiviral activity against membrane viruses (incl. Influenza Virus, and parainfluenza virus).

Lidocaine is a local anesthetic, that inflammatory processes reduces pain in the throat when swallowing.

Pharmacokinetics

Benzoksoniya chloride practically not absorbed. In humans, the active substance in the blood is not defined. The body tissue accumulation of the active substance has been detected. About 1% dose received benzoksoniya chloride found in the urine.

Lidocaine is absorbed by ingestion and through the oral mucosa. It is metabolized in the “first pass” through the liver. When administered orally, the bioavailability is about 35%. Metabolites of lidocaine appear in the urine, less 10% the active substance is excreted unchanged in.

Testimony

Infectious-inflammatory diseases of the oral cavity and pharynx:

- Pharyngitis;

- Laringit;

- Catarrhal angina;

- Stomatitis;

- Ulcerative gingivitis;

- Chronic tonsillitis (as an adjuvant).

Dosage regimen

Adults appoint 1 tab. for sucking every 2-3 Vide hours or spray on 4 spray (about 0.5 ml) 3-6 time / day. When symptom relief can be applied for 1 tab. every 1-2 no. The daily dose should not exceed 10 tablets.

For children 4 and older appoint 1 tab. for sucking every 2-3 Vide hours or spray on 2-3 spray 3-6 time / day. The daily dose should not exceed 6 tablets.

Length of treatment – no more 5 days. If symptom relief is observed within 5 days of therapy, the patient should seek medical advice.

The tablet should dissolve slowly in the mouth until dissolved. The solution is sprayed as a spray to the oral cavity, Hold the can upright.

Side effect

Maybe: Local irritation; when used over a 2 weeks – reversible brown color of tongue and teeth.

Rarely: allergic reactions.

Contraindications

- I trimester of pregnancy;

- Lactation (breast-feeding);

- Children up to age 4 years;

- Hypersensitivity to lidocaine or ammonia compounds.

Pregnancy and lactation

The drug is contraindicated for use in the I trimester of pregnancy and lactation (breast-feeding).

Adequate and well-controlled clinical studies on the safety of drugs in pregnancy has not been. Use of the drug in the II and III trimester is not recommended.

There is no clinical data on the release of active substances in breast milk. Nonetheless, the drug is not recommended for use during breastfeeding.

IN experimental studies No effect of the drug on reproductive function and development of the fetus.

Cautions

During the drug should avoid alcohol.

Overdose

Symptoms: Accidental ingestion of high doses nausea, vomiting. The content of lidocaine in the product is insignificant and can not cause serious symptoms of overdose.

Treatment: It recommended to drink milk or eat the egg white, whipped in water.

Drug Interactions

Efficacy benzoksoniya chloride decreases while using anion-active agents, eg, toothpaste.

Ethanol increases the absorption of chloride benzoksoniya.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children, dry place at temperatures no higher than 30 ° C. Shelf life lozenge – 3 year, spray topical – 5 years.