Sulьfatiazol

When ATH:
J01EB07

Characteristic.

Sulfa drugs short-acting.

White or white with a slightly yellowish white, crystalline powder;. Very slightly soluble in water, few - alcohol, soluble in dilute mineral acids and caustic solutions and carbon alkalis.

Pharmacological action.
Antimicrobial.

Application.

Infection, caused by susceptible microorganisms: pneumonia, meningitis, staphylococcal sepsis and streptokokkovыy, dysentery, gonorrhea and etc..

Contraindications.

Hypersensitivity, inhibition of bone marrow hematopoiesis, renal failure, vrozhdennыy deficiency of glucose-6-fosfatdegidrogenazы, pregnancy, lactation.

Side effects.

Dyspepsia, nausea, vomiting, allergic reactions, leukopenia, neuritis, impairment of renal function (kristallurija).

Cooperation.

Myelotoxicity drugs increase haematotoxicity.

Dosing and Administration.

Inside, adult: pneumonia and meningitis initial dose 2 g, then 1 g every 4-6 hours until the temperature of the body, later taking on 1 g 6-8 h (Heading dose of 20-30 g); When staphylococcal infections initial dose of 3-4 grams, then 1 g 4 times a day for 3-6 days. In dysentery 3-6 grams per day for a special scheme. Children dose is reduced according to age, At first reception given double dose. The maximum dose for adults: single - 2 g, daily - 7 g.

Precautions.

During therapy is recommended sulphathiazole rich alkaline water (2-3 liters of liquid): after each dosing drink 1 glass of water with the addition of 1/2 tsp sodium bicarbonate or 1 a glass of mineral water.

Comment.

By antimicrobial activity is considerably inferior to antibiotics, so now is the second-line drugs and antibiotics used in case of intolerance or develop resistance to them.