Sulbactam

When ATH:
J01CG01

Pharmacological action

Irreversible inhibitor of β-lactamase.

Sulbactam, not having antibacterial activity (exclusion have Neisseriaceae and Acinetobacter), inhibitors Beta-lactamase, are released by microorganisms, resistant to beta-lactam antibiotics; prevents degradation of penicillins and cephalosporins by the action of beta-lactamase-resistant microorganisms; binding to penicillin binding proteins, shows synergy while the use of penicillins and cephalosporins.

Pharmacokinetics

After the / m and / in the introduction to achieve high concentrations in the blood of sulbactam. It penetrates the tissues and body fluids, It passes through the placental barrier, excreted in breast milk. When inflammation of the meningeal membranes of the penetration of the drug into the spinal fluid increases dramatically.

Sulbactam hardly undergoes metabolic transformations.

T1 / 2 is about sulbactam 1 no, excreted mainly unchanged in the urine (70-80%), and with bile. In the form of metabolites derived about 25% product.