Stavudine

When ATH:
J05AF04

Characteristic.

White or off-white crystalline powder. Soluble in water (83 mg / ml).

Pharmacological action.
Antiviral, Inhibitory reverse transcriptase HIV.

Application.

HIV infection, incl. After therapy, zidovudin.

Contraindications.

Hypersensitivity, severe liver.

Pregnancy and breast-feeding.

Prescribing during pregnancy and breastfeeding is permissible only for absolute indications.

Side effects.

Peripheral neurological disorders: (Reducing the sensitivity of the limbs, pricking, myalgia), headache, insomnia, dizziness, abdominal pain, Exacerbation of pancreatitis, dry mouth, anorexia, abnormal liver function, inhibition of hematopoiesis, thrombocytopenia and neytropeniya, Allergic reactions in the form of a skin rash, feverish states.

Cooperation.

Strengthens (mutually) the toxic effect of alcitabin and didanosine effect (in vitro). It is undesirable to use on the background of drugs, capable of causing peripheral neurological disorders, the probability of developing such increases significantly.

Dosing and Administration.

Inside prescribed adults in doses of 30–40 mg 2 once a day, depending on body weight. In the case of toxic manifestations, the drug should be temporarily canceled, then take in a smaller dose - 15–20 mg each 2 once a day. Massions are less 30 kg Stavudin is prescribed in a dose 1 mg / kg / day, With greater body weight, dosage for adults is used; Used for long -term (to 2 years) therapy.

Precautions.

In case of progression of the disease, retroviral therapy correction is necessary. With caution, they are used for impaired liver function and the presence of peripheral neurological disorders. The occurrence of neuropathy requires reduction of the dose. Bilirubin level should be controlled, ALT and AST activity during treatment, especially with concomitant liver and kidney lesions.