Lutropin alfa

When ATH:
G03GA07

Pharmacological action

Recombinant luteinizing hormone, identical to endogenous LH. It participates in the physiological regulation of reproductive function.

Compensates for lack of éndogennogo LG. It stimulates the production of estradiol and follicle formation graafova bubble.

Introduction lutropina alpha mid-cycle to induce the formation of ovulation and corpus luteum.

Introduction lutropina alpha postovulatory period support the functioning of the corpus luteum.

Pharmacokinetics

After p / to the introduction of lutropin alfa is rapidly distributed to organs and tissues. The absolute bioavailability of approximately 60%.

Virtually koumouliruet.

T_1/2 is about 12 no.

Excreted in the urine - less 5% dose.

Testimony

Infertility Treatment, due to hypothalamic-pituitary disorders, leading to a reduction of LH and FSH in the body.

Dosage regimen

Enter n / a. The initial dose - 75 ME.

Treatment is carried out in combination with FSH and hCG formulations by special circuit.

Side effect

Often: headache, stomach ache, breast pain, nausea, vomiting, drowsiness, ovarian cysts.

There are: injection site reactions - pain, redness, itching, puffiness, hematoma; ovarian hyperstimulation (Pain in the lower abdomen, sometimes in combination with nausea, vomiting, weight loss).

When using drugs, containing LH, in rare cases, venous thrombosis, torsion of an ovarian cyst and bleeding into the abdominal cavity, ectopic pregnancy (especially when specifying a history of the primary lesion of the fallopian tubes).

Contraindications

Tumors of the hypothalamic-pituitary region, hyperprolactinemia, adrenal disease and thyroid, persistent increase in ovarian, ovarian cyst, genital malformations (incompatible with normal pregnancy), uterine fibroids, metrorrhagia of unknown etiology, estrogen-dependent tumors (ovarian cancer, uterine cancer, mammary cancer), primary ovarian failure, pregnancy, lactation, hypersensitivity to alpha lutropinu.

Pregnancy and lactation

Contraindicated during pregnancy and lactation.

Cautions

Before treatment, check the fertility of the patient and her partner.

Lutropin alpha is used in combination with FSH, to normalize follicular development, containing egg. Use of hCG leads to release oocytes from the follicle (ovulation).

In the case of ovarian hyperstimulation syndrome should not use hCG, at the same time the patient should abstain from sex or use contraceptives, barrier-type, least, during 4 days.

Before and during treatment should be carefully monitored by the response of the ovaries using ultrasound and blood tests.

There is an increased frequency of multiple pregnancies. To minimize the probability of its occurrence must be observed dosing regimen, recommended for the applicable product.

Drug Interactions

Lutropin Alfa should not be mixed with other medicinal substances except unexposed controls alpha, tk. studies showed, These two drugs may be mixed and administered simultaneously without affecting the therapeutic activity.