Ketotifen
When ATH:
R06AX17
Pharmacological action.
Membrane stabilizing, antiallergic, antihistamine, antiasthmatic.
Application.
Inside: prevention of allergic diseases: bronchial asthma (atopic form), allergic bronchitis, pollen disease; prevention and treatment of allergic rhinitis, allergic conjunctivitis, krapivnicы (acute, chronic), atopic dermatitis.
Konъyunktyvalno: prevention and treatment of allergic conjunctivitis.
Contraindications.
Hypersensitivity, pregnancy, lactation, Children up to age 3 years (tablets, eye drops) or 6 Months (syrup).
Restrictions apply.
Epilepsy, hepatic failure.
Pregnancy and breast-feeding.
Contraindicated.
Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)
At the time of treatment should stop breastfeeding.
Side effects.
If ingestion
From the nervous system and sensory organs: sedation, slowing the rate of reaction, lethargy, feeling tired, dizzy, headache, drowsiness, rarely is a concern, sleep disturbance, nervousness (especially in children).
From the digestive tract: dry mouth, increased appetite, nausea, vomiting, gastralgia, constipation.
Other: thrombocytopenia, dizurija, cystitis, weight gain, allergic skin reactions.
In applying the conjunctival
On the part of the eye: conjunctival hyperemia, headache, rhinitis, allergic reactions, burning eyes, conjunctivitis, discharge from the eyes, dry mucous membranes of the eyes, sore eyes, violations of the Century, incl. rash, itch, keratit, violation of lacrimation, midriaz, photophobia.
Other: flu-like symptoms, pharyngitis.
Cooperation.
It enhances the effects of sedatives, hypnotics, other antihistamines and ethanol. Oral antidiabetic drugs increase the likelihood of developing thrombocytopenia.
Overdose.
Symptoms: drowsiness, nistagmo, confusion, disorientation, Beards- or tachycardia, low blood pressure, breathlessness, cyanosis; convulsions, hypererethism (especially in children); may develop coma.
Treatment: induction of vomiting, gastric lavage, appointment of activated carbon, laxatives; simptomaticheskaya therapy: maintaining vital functions, When the excitation and convulsions — introduction short acting barbiturates or benzodiazepines. Dialysis nyeeffyektivyen.
Dosing and Administration.
Inside (while eating), adults - 1 mg 2 once a day (in the morning and in the evening). If necessary, the daily dose is increased to 4 mg (by 2 mg 2 once a day). Patient, in which there is a significant sedation, slow increase in the dose recommended for the first week, beginning with 0,5 mg in the evening before going to bed, to gradually achieve a therapeutic dose.
Children over 3 years - 1 Table. (1 mg) or 5 ml syrup 2 once a day (in the morning and in the evening); from 6 Months before 3 years - 2,5 ml syrup (0,5 mg) 2 once a day, in the morning and in the evening.
The therapy is prolonged, effect is achieved after several weeks of treatment. Treatment should be carried out for at least 2-3 months, especially in patients, which effect was not observed in the first week. Discontinuation of therapy should be gradually ketotifen, within 2-4 weeks.
Konъyunktyvalno, adults and children over 3 instill years 1 drop into the affected eye every 8-12 hours. The course of treatment - at least 6 Sun.
Precautions.
Not intended for acute asthma. It is not recommended immediately cancel previous therapy beta-agonists, gljukokortikoidami, ACTH (cancellation is carried out for at least 2 Sun, gradually reducing the dose). Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention. Patients, simultaneously receiving oral hypoglycemic agents, should control the number of platelets in peripheral blood. It should be taken into account, syrup contains ethyl alcohol (2,35 volume %) and carbohydrates (0,6 g / ml).
