Fluticasone (When ATH R01AD08)
When ATH:
R01AD08
Characteristic.
White or off-white powder, almost insoluble, soluble in dimethyl sulfoxide and dimethylformamide, slightly soluble in methanol and 95% ethanol.
Pharmacological action.
Anti-inflammatory, antiallergic, protivozudnoe.
Application.
Nasal Spray - Allergic Rhinitis; inhaler - prevention of exacerbations of bronchial asthma; cream and ointment - eczema, nodular pruritus (Bagpipe), psoriasis, neyrodermatozy (including lichen simplex), Lichen planus, contact hypersensitivity response, discoid lupus erythematosus, generalized erythroderma, insect bites, Red sudamen, seborrheic dermatitis.
Contraindications.
All forms: hypersensitivity, pregnancy, lactation; ointment and cream: acne (pink, ordinary), perioral dermatitis, perianal and genital itching, primary skin lesions of bacterial, viral and fungal etiology, infancy (to 1 year); Aerosol spray: childhood (to 4 years).
Pregnancy and breast-feeding.
Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)
Side effects.
Nazalynыy spray - Irritation of the nose, unpleasant taste and smell, perforation of the nasal septum; aerosol inhalation - Candidiasis of the oral mucosa, hoarseness, development of paradoxical bronchospasm; cream and ointment - Burning and itching at the site of application, striae, gipopigmentatsiya, hypertryhoz, contact type allergy; with prolonged use - symptomatic hypercortisolism.
Dosing and Administration.
Intranasal, locally, inhalation. Nasal Spray - in the morning after 100 g (children under 12 years - 50 g) in each nostril; aerosol for inhalation - for mild bronchial asthma, moderate and severe 2 once a day, 100-250 mcg, 250-500 mcg and 500 μg respectively (children and adolescents up to 16 years - 50-100 mcg); ointment and cream is applied with a thin layer on the affected area of the skin 2 once a day.
Precautions.
Be wary appointed after systemic use of glucocorticoids, especially when dysfunction of the adrenal glands, inhalation aerosol - for pulmonary tuberculosis. Nasal Spray is recommended at regular intervals; aerosol inhalation treatment should not be stopped abruptly, before the procedure, it is desirable to inhaled beta agonist2-adrenergic short-acting, and after that - rinse your mouth. Avoid getting the cream or ointment in the eye, before applying a new bandage the treated skin.
