Enoxaparin sodium

When ATH:
B01AB05

Characteristic.

Low molecular weight heparin with an average molecular weight 4500 Dalton.

Pharmacological action.
Antithrombotic.

Application.

Prevention of venous thromboses and thromboembolisms (especially in orthopedics and general surgery), as well as in patients with acute therapeutic diseases, It is on bed rest; treatment of deep vein thrombosis; prevention of clotting in the extracorporeal circuit during hemodialysis; Treatment of unstable angina and myocardial infarction without Q wave (in combination with acetylsalicylic acid).

Contraindications.

Hypersensitivity, a high risk of uncontrolled bleeding, including acute peptic ulcer, wounds, hemorrhagic stroke.

Pregnancy and breast-feeding.

Acceptable if strict indications.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

Side effects.

Thrombocytopenia (asymptomatic, immuno-allergic), intraspinal hematoma (spinal anesthesia) and paralysis, elevated liver enzymes, cutaneous or systemic allergic reactions, bleeding; at the site of injection is inflammation, pain, hematoma, nodes, nekrozy.

Cooperation.

Incompatible with other, vliyayushtimi of gemostaz, preparations: NSAIDs (in addition to acetylsalicylic acid), dextran 40, ticlopidine, thrombolytics, etc..

Overdose.

Symptoms: angiostaxis.

Treatment: slow in / in a Protamine.

Dosing and Administration.

P /, supine antero- and posterolateral region of the abdominal wall at waist level. Prevention of postoperative venous trombozov and tromboamboliy — 20 mg 1 once a day for 7 days (the first dose for 2 hours before the operation), at very high risk of — 40 mg/kg daily, during 10 days (the first dose for 12 hours before the operation).

Thrombosis of deep veins is on 1 mg / kg every 12 or h 1,5 mg / kg 1 once a day for 10 days.

Prevention coagulation in gemodialise-0.5-1 mg/kg in the arterial line at the beginning of haemodialysis, conducted during the 4 no.

Treatment of unstable angina and myocardial infarction without zubza Q is on 1 mg / kg every 12 h to stabilize (usually 3-8 days), in patients receiving aspirin.

Precautions.

You can not enter the / m. When thrombocytopenia, heparin-induced, history can appoint in exceptional cases because of the risk of immuno-allergic thrombocytopenia, manifested through 5-24 days. By reducing the number of platelets below 50% standards cancel enoxaparin.