Benzokain (When ATH N01BA05)

When ATH:
N01BA05

Characteristic.

The white crystalline powder;, slabogorkogo taste; It is the language of feeling numb. 1 g benzocaine soluble in 2500 ml of water, 5 ml ethanol, 4 ml ether, 2 ml of chloroform, a fatty oils (from 30 to 50 ml), in dilute hydrochloric acid. pKa 2,5. Molecular weight 165,19.

Pharmacological action.
Mestnoanesteziruyuschee.

Application.

Inside: gastralgia, esophagitis, gastric ulcer and duodenal ulcer. Locally: acute inflammation of the middle ear, pain in the external auditory meatus, hives, skin diseases, accompanied by itching; perianal fissures, hemorrhoids. Perform diagnostic procedures on the mucous membranes (gastroscopy, rectoscopy, otoscopy, urethroscopy, gynecological procedures). In dentistry: permeation anesthesia.

Contraindications.

Hypersensitivity.

Restrictions apply.

Childhood (to 2 years).

Pregnancy and breast-feeding.

In pregnancy, the use is possible only if necessary (unknown, Does benzocaine adverse fetal effects and effects on the reproductive capacity).

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Precautions during breastfeeding (unknown, whether benzocaine gets into breast milk).

Side effects.

Contact dermatitis and / or hypersensitivity reactions (burning, pricking, itch, эritema, rash, hives, edema), sustained reduction in sensitivity at the application site; rarely, excessive use - methemoglobinemia (especially in infants and young children).

Cooperation.

Cholinesterase inhibitors inhibit the metabolism of benzocaine.

Overdose.

Symptoms: metgemoglobinemiâ, breathlessness, cyanosis, dizziness.

Treatment: symptomatic and / intravenous methylene blue.

Dosing and Administration.

Inside, outwardly. Outwardly, applied to the affected area in the form of 5% ointment, solution, powders. When inflammation of the hearing aid - 4-5 drops into the ear canal, followed by tamponade cotton cloth, applique repeat (in case of need) every 1-2 hours.

Inside, adults - 0,3 g 3-4 times a day; Higher doses for adults: single - 0,5 g, daily - 1,5 g. Doses for children - depending on their age.

In dentistry. Locally 5-20% solution in an oil or glycerol is applied to the oral mucosa, powder or paste 50-70% - for pain of dental hard tissues.