Aztreonam

When ATH:
J01DF01

Characteristic.

Derivative betalaktaminov, having one (beta lactam) ring.

The white crystalline powder;. Very slightly soluble in ethanol, slightly soluble methanol, soluble in dimethylformamide, dimethyl sulfoxide. Practically insoluble in toluene, xloroforme, ethyl acetate.

Pharmacological action.
Antibacterial, bactericide.

Application.

Severe generalized systemic infections, caused by Gram-negative microorganisms: urinary tract infections, septicemia, lower respiratory tract infections (incl. pneumonia, bronchitis), skin and soft tissue, pelvic, bones, localized parenchymal abscess, especially in debilitated patients and in disorders of the immune system; prevention of perioperative infections.

Contraindications.

Hypersensitivity, pregnancy, lactation, the neonatal period.

Pregnancy and breast-feeding.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

At the time of treatment should stop breastfeeding.

Side effects.

Headache, confusion, increased perspiration, increased prothrombin time, thrombocytopenia, diarrhea, nausea, vomiting, taste disturbance, increase in AP, ALT IS, pain in the muscles and bones, skin rashes, itch, phlebitis and thrombophlebitis at / introduction, discomfort at the site of the / m.

Cooperation.

Strengthens (mutually) the antibacterial effect of penicillins, cephalosporins, aminoglycosides, klindamiцina, metronidazola.

Overdose.

Characterized polymorphic (nonspecific) manifestations.

Treatment: symptomatic, gemo- ili pyeritonyealinyi dialysis.

Dosing and Administration.

/ M, I / bolus and infusion. Doses set individually depending on the location and severity of the infection, susceptibility. For adults, a single dose is 0.5-2 g (patients with acute violations of the kidney-half dose) every 8-12 hours, The maximum daily dose - 8 g; for children over 1 weeks — on 30 mg / kg, senior 2 years - 50 mg/kg every 6-8 hours.

Precautions.

Precautions should be prescribed at the failure of the liver, allergic reactions, incl. drug-induced. For children up to 6 s Do not use solvents, containing benzyl alcohol.